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Chloe (voice of Drew Barrymore), a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious lifestyle so much, she hardly notices Papi (voice of George Lopez), a tough looking Chihuahua who happens to be head-over-paws for the pampered pooch. But when Chloe gets lost in the rough streets of Mexico with only a street-wise German Shepherd (voice of Andy Garcia) to help her find her way home, Papi heads south of the border - joining forces with a motley crew: two humans (Piper Perabo, Manolo Cardona), a sly rat (voice of Cheech Marin) and a nervous iguana (voice of Paul Rodriguez) – to rescue his true love.
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